Brain Structural Signatures of Adolescent Depressive Symptom Trajectories: A Longitudinal Magnetic Resonance Imaging Study

L Schmaal; M Yücel; R Ellis; N Vijayakumar; JG Simmons; NB Allen; S Whittle

Journal article

Brain Structural Signatures of Adolescent Depressive Symptom Trajectories: A Longitudinal Magnetic Resonance Imaging Study

L Schmaal, M Yücel, R Ellis, N Vijayakumar, JG Simmons, NB Allen, S Whittle

Journal of the American Academy of Child and Adolescent Psychiatry | ELSEVIER SCIENCE INC | Published : 2017

DOI: 10.1016/j.jaac.2017.05.008

Abstract

Objective Most evidence for structural brain abnormalities associated with adolescent depression is based on cross-sectional study designs that do not take into account the dynamic course of depressive symptoms and brain maturation across adolescence. In this study, a longitudinal design was used to investigate the association between different trajectories of depressive symptoms and longitudinal changes in brain structure throughout adolescence. Method One hundred forty-nine adolescents were assessed on depressive symptoms and underwent structural magnetic resonance imaging at 12 years of age and were followed up multiple times until 19 years. Three depressive symptom trajectories (low-stab..

View full abstract

University of Melbourne Researchers

Lianne Schmaal Author

Nandita Vijayakumar Author

Julian Simmons Author

Nick Allen Author

Related Projects (2)

Sensitivity to the environment: Risk and resilience for adolescent depression

Depression is among the leading causes of disability and disease burden throughout the world. Little is known about how biological and envir..

Brain development during adolescence and the emergence of depression: A longitudinal MRI study.

Traditionally mental health services have focused on established disorders. Whilst significant gains in outcomes have been obtained in other..

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by Australian Research Council

Awarded by Netherlands Brain Foundation

Awarded by Neuroscience Campus Amsterdam

Awarded by NHMRC of Australia

Awarded by NHMRC Career Development Fellowship

Funding Acknowledgements

This research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Program Grant 3502411 of Australia, and the Australian Research Council (Discovery Grant DP0878136). Dr. Schmaal gratefully acknowledges support from the foundation De Drie Lichten in The Netherlands, The Netherlands Brain Foundation (F2014[1]-24), and the Neuroscience Campus Amsterdam (IPB-SE-15-PSYCH-Schmaal). Dr. Yucel was supported by the NHMRC of Australia (ID APP1021973), and Dr. Whittle is supported by an NHMRC Career Development Fellowship (ID 1007716).